Cancer cells must be able to produce energy and macromolecules to make daughter cells. This requires a reorganization of the metabolic activities used by resting cells.
An emerging concept is that metabolism in cancer cells is regulated by growth factors and the signal transduction pathways they stimulate. We seek to define mechanisms by which these pathways disturb cellular metabolism. Defining the metabolic activities that are dysregulated in tumors may suggest new therapeutic targets in cancer.
Our fundamental goals are to discover new roles for metabolites that affect metabolism in cancers, and to discover metabolic vulnerabilities of cancer cells that can be targets for therapy.